BioNMR in drug research

Pt. I. Basic Techniques

1. Modern Methods for the Expression of Proteins in Isotopically Enriched Form / Heiko Patzelt, Natalie Goto, Hideo Iwai, Kenneth Lundstrom and Erhard Fernholz

2. Structure Calculation Using Automated Techniques / Peter Guntert

3. Achieving Better Sensitivity, Less Noise and Fewer Artifacts in NMR Spectra / Detlef Moskau and Oliver Zerbe

Pt. II. NMR of Biomolecules

4. NMR Strategies for Protein Assignments / Volker Dotsch

5. NMR of Membrane-Associated Peptides and Proteins / Reto Bader, Mirjam Lerch and Oliver Zerbe

6. NMR of Nucleic Acids / Radovan Fiala and Vladimir Sklenar

Pt. III. Modern Spectroscopic Techniques

7. Methods for the Measurement of Angle Restraints from Scalar, Dipolar Couplings and from Cross-Correlated Relaxation: Application to Biomacromolecules / Christian Griesinger

8. Orientational Restraints / Eva de Alba and Nico Tjandra

9. Scalar Couplings Across Hydrogen Bonds / Andrew J. Dingley, Florence Cordier, Victor A. Jaravine and Stephan Grzesiek

10. TROSY: Transverse Relaxation-Optimized Spectroscopy / Roland Riek

11. MAS Solid-State NMR of Isotopically Enriched Biological Samples / Philip T. F. Williamson, Matthias Ernst and Beat H. Meier

12. Determination of Protein Dynamics Using [superscript 15]N Relaxation Measurements / David Fushman

Pt. IV. Tools for Investigation of Drug - Receptor Complexes and for Ligand Screening

13. Determination of Equilibrium Dissociation Constants of Protein-Ligand Complexes by NMR / Gordon C. K. Roberts

14. Experiments in NMR-Based Screening / Carla Marchioro, Silvia Davalli, Stefano Provera, Markus Heller, Alfred Ross and Hans Senn

15. Use of Spin Labels in NMR-Supported Lead Finding and Optimization / Wolfgang Jahnke

16. NMR of Weakly Binding Ligands / Marcel J. J. Blommers and Simon Rudisser

17. Isotope Filter and Editing Techniques / Gerd Gemmecker

Pt. V. Strategies for Drug Development Using NMR

18. Strategies for NMR Screening and Library Design / Christopher A. Lepre

19. Strategies for Hit Finding Using NMR / Werner Klaus and Hans Senn

20. Strategies for Drug Discovery Using NMR / Marcel J. J. Blommers, Andreas Florsheimer and Wolfgang Jahnke

21. NMR-Based Drug Design: Approaches for Very Large Proteins / Maurizio Pellecchia, Xuemei Huang, David Meininger and Daniel S. Sem.